As an important national strategy, the security of cereal and oil plays a key role in maintaining social stability, promoting the rural revitalization strategy and keeping a sustained, rapid and sound development of national economy. With rapid increase of global population and continous development of food industry, the more diversified, healthy and low-carbon cereal and oil products have been preferred by consumers. However, in China, the development of cereal and oil industries is constrained by many problems, including limited cereal and oil processing resources, poor green processing technology, lack of moderate processing means, unclear mechanism of nutritional factors, and difficulty in hazard risk control. With the development of life science, information technology and materials technology, future food science and technology of cereal and oil based on food omics, synthetic biology, nutrition and materials science are expected to meet the above challenges from the technical level. This paper outlined the status and role of cereal and oil food industries in the national economy, and summarizedthe development trend and market conditions of cereal and oil industries. In China, the technical challenges faced by cereal and oil in China, grain, oil and food science and technology were also introduced, and the future development trend of grain, oil and food science and technology will also be prospected, including moderate oil processing, green grain production, intelligent safety control, and precise nutrition supply.