To explore the ingredients and possible mechanisms of Mulberry for controlling coronary heart disease of liver and kidney yin deficiency based on network pharmacology and molecular docking. The active components and common targets of Mulberry combating coronary heart disease of liver and kidney yin deficiency were obtained from TCMSP, TCMID, Swiss TargetPrediction, and GeneCards databases; cytoscape software was used to generate component-target-disease interaction network diagram. PPI network was constructed and analyzed by STRING database; with the help of DAVID database, the GO function analysis and KEGG pathway enrichment analysis were carried out, and finally Schrödinger Maestro was used to verify the molecular docking of main active ingredients and key targets. There were 14 active components in Mulberry, and 134 target genes were associated with coronary heart disease of liver and kidney yin deficiency. Predicted target genes mainly acted on TNF, PI3K/AKT signaling pathways to prevent and treat coronary heart disease with liver and kidney yin deficiency by regulating inflammation, apoptosis and blood circulation. Molecular docking results showed that the main active ingredients had good binding properties with candidate target proteins. The study preliminarily reveals that Mulberry can prevent and treat coronary heart disease of liver and kidney yin deficiency through multi- components, multi-targets and multi-pathways. The results can provide theoretical reference and new research direction for the development of Mulberry and functional foods for controlling the coronary heart disease of liver and kidney yin deficiency.