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基于网络药理学研究核桃粕的降脂机理(网络首发、推荐阅读)
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Network Pharmacology-based Research on Lipid Lowering Mechanism of Walnut Cold-press Meal(Online First, Recommended Article)
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    基于网络药理学方法探究核桃粕降脂的作用机理。通过TCMSP数据库和文献挖掘获得核桃粕的活性成分及相应潜在靶点;使用GeneCards等数据库进行高脂血症(HLP)相关基因预测和筛选;采用Cytoscape 3.7.2软件构建“药物–活性成分–疾病–靶点”网络以形成核桃粕防治HLP的成分及靶点相互作用关系,并进行GO功能和KEGG通路富集分析。结果表明,筛选获得14种核桃粕活性成分,其中7种成分具有HLP相关靶点59个,HAS2、NCOA2、ESR1、CAT、AR、VEGFA和POR可能是HLP的关键靶点,主要信号通路为HIF-1信号通路、TNF信号通路、南美锥虫病、疟疾信号通路。核桃粕通过多成分、多靶点、多途径防治HLP,其中作用靶点最多的成分为槲皮素、芦丁、儿茶素、芥子酸和鞣花酸;受最多化合物作用的靶点为透明质酸合酶2、核受体辅活化因子2、雌激素受体、过氧化氢酶、雄激素受体、血管内皮生长因子A和NHLPPH-细胞色素P450还原酶。

    Abstract:

    This paper explores the action mechanism of walnut cold-press meal in reducing fat from the perspective of network pharmacology. Active components and potential targets of walnut cold-press meal were obtained through TCMSP database and literature mining. GeneCards and other databases were used to predict and screen Hyperlipidemia (HLP) related genes, while Cytoscape 3.7.2 software was applied to construct a “drug-active component-disease-target” network to the formation of walnuts to prevent HLP components and target interactions, and analysis of GO function and KEGG pathway enrichment. Results show that 14 active components of Walnut cold-press meal were identified, among which 7 components have 59 HLP-related targets. HAS2, NCOA2, ESR1, CAT, AR, VEGFA and POR may be the key targets of HLP, with the main signaling pathways being HIF-1 signaling pathway, TNF signaling pathway, Chagas disease, and malaria signaling pathway. HLP is prevented by multi-component, multi-target and multi-pathway, among which the most targeted components are quercetin, rutin, catechin, erucic acid and ellagic acid. Targets most affected by the compounds are hyaluronate synthase 2, nuclear receptor coactivator factor 2, estrogen receptor, catalase, androgen receptor, vascular endothelial growth factor A and NHLPPH-- cytochrome P450 reductase.

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郭 琰,马雅鸽,张 希,陈朝银,赵声兰*.基于网络药理学研究核桃粕的降脂机理(网络首发、推荐阅读)[J].粮油食品科技,2021,29(4):144-152.

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  • 在线发布日期: 2021-07-29
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