This study aims at sulfuryl fluoride fumigation in large warehouses. By comparing and analyzing the penetration, uniformity and insecticidal effect of three different methods of application in the real warehouses. The best technology for sulfuryl fluoride fumigation in the real warehouses was explored. Research results show that sulfuryl fluoride gas can diffuse through the grain pile naturally within 2.5 hours, and penetrate the entire warehouse within 24 hours. Recirculation fumigation can accelerate the uniformity of the gas, but it causes more chemical loss. Among the three fumigation methods, the whole warehouse fumigation operation is the simplest and the most effective in killing adults. The upward recirculation fumigation under the membrane causes large chemical loss, while for the downward recirculation fumigation under the membrane, the concentration is uniformly distributed, even though the dosage is smaller. The concentration of the agent is maintained for a long time, and the insecticidal effect is significant.