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黑芝麻油卵磷脂溶液对自然生长老龄小鼠骨代谢的影响(网络首发、推荐阅读)
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Effect of Black Sesame Oil Lecithin Solution on Bone Metabolism in Naturally Growing Aged Mice(Online First, Recommended Article)
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    观察黑芝麻油卵磷脂溶液对自然生长老龄小鼠骨代谢的影响,并与维生素E比较。8月龄SPF级的昆明小鼠,随机分为生理盐水组(NS组),维生素E组(VE组),黑芝麻油组(Oil组),实验持续10周,结束时,处死小鼠,取右侧股骨进行微计算机断层扫描技术(Micro CT)扫描,左侧尺骨进行骨成分含量测定。结果表明:与NS组相比,Oil组骨钙和骨镁含量均显著增加,结构模型指数(SMI)显著降低,而骨体积分数(BV/TV)、骨密度(Density)和骨小梁连接密度(Conn-Dens)均有所增加,但差异无统计学意义;与VE组相比,Oil组骨钙和骨镁含量均显著增加;三维图可见其骨小梁分布排列均匀紧密有序,间隙较小,且连续性较好。自然生长的老龄小鼠给予黑芝麻油卵磷脂溶液10周后,小鼠股骨的骨量有增加,微观结构得到改善,提示有抗骨质疏松应用的潜力。

    Abstract:

    To observe the effect of black sesame oil lecithin solution on bone metabolism in naturally grown aging mice and compare with vitamin E. 8-month-old SPF Kunming mice were randomly divided into normal saline group (NS group), vitamin E group (VE group), black sesame oil group (Oil group). The experiment lasted for 10 weeks. At the end of the experiment, the mice were sacrificed. The right femurs were taken for Micro CT scan, and the left ulna for bone component content determination. Compared with the NS group, the bone calcium and bone magnesium contents in the Oil group were significantly increased, and the SMI was significantly reduced, while BV/TV, Density and Conn-Dens were increased, but the difference was not statistically significant; compared with the VE group, The content of bone calcium and bone magnesium in the Oil group were significantly increased; the three-dimensional map showed that the bone trabeculae were arranged evenly and tightly, with small gaps and good continuity. After 10 weeks of naturally-growing old mice given black sesame oil, the bone mass and microstructure of the femur of the mice increased, suggesting the potential applications for anti-osteoporosis.

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吕思敏,黄志荣,于 琼,孙金影,崔 燎,吴 铁*.黑芝麻油卵磷脂溶液对自然生长老龄小鼠骨代谢的影响(网络首发、推荐阅读)[J].粮油食品科技,2021,29(2):173-179.

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  • 在线发布日期: 2021-03-23
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