To observe the effect of black sesame oil lecithin solution on bone metabolism in naturally grown aging mice and compare with vitamin E. 8-month-old SPF Kunming mice were randomly divided into normal saline group (NS group), vitamin E group (VE group), black sesame oil group (Oil group). The experiment lasted for 10 weeks. At the end of the experiment, the mice were sacrificed. The right femurs were taken for Micro CT scan, and the left ulna for bone component content determination. Compared with the NS group, the bone calcium and bone magnesium contents in the Oil group were significantly increased, and the SMI was significantly reduced, while BV/TV, Density and Conn-Dens were increased, but the difference was not statistically significant; compared with the VE group, The content of bone calcium and bone magnesium in the Oil group were significantly increased; the three-dimensional map showed that the bone trabeculae were arranged evenly and tightly, with small gaps and good continuity. After 10 weeks of naturally-growing old mice given black sesame oil, the bone mass and microstructure of the femur of the mice increased, suggesting the potential applications for anti-osteoporosis.