Hundreds of millions of bacteria adhere to human intestinal epithelium, which are the participants of human health and physiological functions, and also an important target covered by the concept of comprehensive health. So far, the supplementation of prebiotics remainsare still one of the effective means to regulate intestinal microbiota and promote the growth of beneficial microbes. The by-productsof grain and oil processing are abundant in variety and yield, and many of them can be utilized by human intestinal microbiota, which are one of the sources of high-quality prebiotics, and also the important material basis and raw material source in the development of “microbial-oriented food”.