Lycopene has a positive effect on delaying senility, anti-atherosclerosis, cancer prevention and anti-cancer, and prevention of cardiovascular diseases due to its strong antioxidant activity. But it has some disadvantages, such as lack of stability, low bioavailability caused by the property of fat- solubility, which limit the application. Therefore, it is of great value to improve the stability, water solubility and bioavailability of lycopene after being treated by preparation process. The preparation technology of lycopene, including microencapsulation technology, liposome technology, nano dispersion technology, embedding technology, emulsification technology and supercritical fluid technology, are reviewed.