The technology of extracting polysaccharide from fructus choerospondiatis by microwave-assisted enzymetic method was optimized by Box-Benhnken central composite design and response surface analysis based on the single factor experiment with enzyme dosage, pH, enzymolysis temperature and microwave extraction time as the factors and the extraction yield of polysaccharides as the response value.The results showed that the optimal conditions of extraction were as followings: enzyme dosage 1.2% , pH 5.5, enzymolysis temperature 45 ℃ ,and microwave extraction time 8 min. Under the conditions, the yield of polysaccharide from fructus choerospondiatis was up to 42.56%.