Based on single factor experiment, phosphoric acid was chosen as degumming agent of wheat germ oil. The mathematical model between the amount of phosphoric acid, water, temperature, stirring time and the phospholipid content in the degummed oil was established by central composite design and response surface optimization. The optimum degumming conditions were as follows: amount of phosphoric acid 0.51％, degumming temperature 60 ℃, time 31 min, the amount of water 3.53 times of the initial content of phospholipid. The phospholipid content of degummed wheat germ oil was 9.31 mg/kg which was close to the predicted value 9.10 mg/kg. Therefore, the model was feasible to forecast the degumming results under different technology.