China has entered a new economic development status named "new normality". The new international and national situation and new requirements which the work of maintaining the grain quality and safety would face to were analyzed. The potential risks and hidden danger on grain quality and safety problems were judged objectively. The problem-oriented principle was adopted, the dialectical thinking, creative thinking, strategic thinking and bottom-line thinking were applied, methodology and studied the possible path to solve the grain quality and safety problems in China. Practical suggestions were proposed from a comprehensive, developing and whole viewpoint, including finding new potentials on improving the supervision ability, creating new paths on optimizing supervision pattern, promoting higher income for farmers and ensuring the grain quality and safety. Our study was expected to provide a powerful support on realizing agricultural modernization and building a well-off society in an all-round way.