Lateral ventilation is convenient to load and unload grain and saves a lot of manpower and material resources in the warehouse. The uniformity of air flow and cooling effect of the lateral ventilation need being further studied. Based on the theory of heat and mass transfer in porous medium, a mathematical model of coupled heat and moisture transfer in warehouse during the cooling ventilation was derived. According to computational fluid dynamics (CFD) method, lateral ventilation for cooling wheat was conducted with two-dimensional numerical simulation analysis. By numerical simulation study on cooling lateral ventilation, the heat transfer and moisture migration in stored grain was analyzed, and it was found that lateral ventilation was uniform and cooling effect for stored grain was significant. This study also laid a foundation for the future operation and management of ventilation.