Fumonisin (FB) is a kind of water soluble secondary metabolites produced from genus fusarium under a certain temperature and humidity condition. It not only greatly pollutes grain crops which will cause reduction of output but cause huge damage to humans and animals. Recently, degradation of FB has become a research hotspot. Although the traditional physical and chemical methods can reduce part of fumonisins the degradation is not complete, the nutritional components are damaged and some uncertainty is introduced, while the reactions by biological methods are mild, high efficiency and friendly to environment. Now, the research on degradation of FB has reached molecular levels. Correlative degrading bacteria have been filtrated and some degrading genes have been cloned. The research progress in degradation of FB was summarized. The advice for degradation of FB was proposed.