Response surface methodology was applied to achieve the optimal conditions of ultrasonic-assisted extraction of total flavonoids from tatary buckwheat shell. Base on single factor experiments, ultrasonic power, extraction time, temperature and liquid-solid ratio were chosen as influence factors on the yield of total flavonoids according to the principle of Box-Behnken central composite design. 60% (volume) alcohol was used as an extraction solvent, the results showed that the optimal extraction conditions were ultrasonic power of 50 W, extraction time of 26 min, extraction temperature of 53 ℃, liquid-solid ratio of 49 mL g-1, and extraction times of 2. Under the optimal conditions, the extraction rate of total flavonoids was 2.02 %.The optimal extraction conditions were reasonable and reliable, which provided technical support for the utilization of total flavonoids from tatary buckwheat shell.