Vitamin B2 microcapsule was prepared by spray-drying technique using arabic gum as wall material and vitamin B2 as core material. The effects of technological parameters, including ratio of wall to core, wall material concentration, inlet temperature and feeding rate, on microencapsulation efficiency were investigated. The optimal microencapsulation condition was obtained by single factor and orthogonal experiments which was ratio of wall to core 10∶1, the concentration of wall material 20%, inlet temperature 170 ℃, and feeding rate 3 mL/min. Under the optimum condition, the vitamin B2 microcapsule embedding rate reached to 86.12%.