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The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs
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The Challenge of Standard Stability in LC-MS Based Multi-Analyte Approaches for Veterinary Drugs

Lidija Kenjeric1, Michael Sulyok2, Alexandra Malachova1, David Steiner4, Rudolf Krska2,3*, Brian Quinn3, Brett Greer3, Christopher T.Elliott3

(1. FFoQSI GmbH, FFoQSI Austrian Competence Centre for Feed & Food Quality, Safety and Innovation, 3430 Tulln, Austria; 2. Institute of Bioanalytics and Agro-Metabolomics, Department of Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna, 3430 Tulln, Austria; 3. Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, University Road, Belfast, BT7 1NN, Northern Ireland, United Kingdom; 4. Romer Labs Diagnostic GmbH, Analytical Service Department, Technopark 5, 3430 Tulln)

Abstract: The short- and long-term stability of multi-component mixtures and intermediate mixtures of analytical standards of veterinary drugs, which can potentially occur in food and feed chains, was examined by an isochronous measurement approach. Short-term stability testing of calibrants included storage for 1, 2, 4, and 7 days at –20 (as a baseline) 4 , and 23 (with and without exposure to sunlight), respectively. Long-term stability testing conditions of intermediate mixes were –20 , 4 , 23 (with and without exposure to sunlight), and control temperature at –80 while the testing period was 2, 4, 8, and 12 weeks, respectively. Results indicated that calibration standards should ideally be stored at 4 for only 1~2 days, without the presence of acid. Neutral storage conditions were acceptable even at room temperature. Storage of intermediate mixtures containing ß-lactams and cephalosporins for longer than 1 month under 4 and room temperature resulted in a loss of almost 90%. When it comes to the intermediate mixtures with penicillin V and G, acceptable storage conditions were 2 weeks at –20 , without the presence of acid. Other classes of veterinary drugs were less critical as considers long-term stability. Overall, storage conditions at –20 were considered optimal for long-term storage of intermediate mixes of veterinary drug standards.
Key words: veterinary drugs; long-term stability; short-term stability; isochronous measurement; LC-MS/MS

Chinese Library Classification Number: TS207.3; S859.84

Documentary Identification Code: A    Article ID: 1007-7561(2021)06-0100-06

Published time on CNKI: 2021-11-02 16:19:14

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Published date:2021-12-07Click:

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