2021, 29(4):144-152.
Abstract:
This paper explores the action mechanism of walnut cold-press meal in reducing fat from the perspective of network pharmacology. Active components and potential targets of walnut cold-press meal were obtained through TCMSP database and literature mining. GeneCards and other databases were used to predict and screen Hyperlipidemia (HLP) related genes, while Cytoscape 3.7.2 software was applied to construct a “drug-active component-disease-target” network to the formation of walnuts to prevent HLP components and target interactions, and analysis of GO function and KEGG pathway enrichment. Results show that 14 active components of Walnut cold-press meal were identified, among which 7 components have 59 HLP-related targets. HAS2, NCOA2, ESR1, CAT, AR, VEGFA and POR may be the key targets of HLP, with the main signaling pathways being HIF-1 signaling pathway, TNF signaling pathway, Chagas disease, and malaria signaling pathway. HLP is prevented by multi-component, multi-target and multi-pathway, among which the most targeted components are quercetin, rutin, catechin, erucic acid and ellagic acid. Targets most affected by the compounds are hyaluronate synthase 2, nuclear receptor coactivator factor 2, estrogen receptor, catalase, androgen receptor, vascular endothelial growth factor A and NHLPPH-- cytochrome P450 reductase.
