Quinoa saponins are a kind of pentacyclic triterpenoids with important physiological and pharmacological activities. Due to the wide variety and wide polarity span, the conventional purification and separation methods not only require a lot of work, but also easily lead to the omission of some rare saponins. There have been some experimental studies on the purification of quinoa saponins at home and abroad. However, the introduction time of quinoa in China is relatively short, and the related accumulation is relatively weak. In order to better sort out and promote the relevant research on the separation and purification technology of quinoa saponins, it is necessary to summarize the methods for purifying quinoa saponins domestically and internationally, and analyze the key technical points (such as n-butanol extraction, macroporous resin adsorption, C18 chromatographic column purification, HPLC system purification, foam collection purification, ultrafiltration concentration purification, etc.). This paper also introduced the separation methods of monomer saponins from the total saponins, and prospected the significance of bioactivity-oriented separation of saponins monomers. This review has the important reference value for the isolation and purification of quinoa saponins.