This research aims to prepare Astaxanthin Gelatin-Gum Arabic microspheres and to explore its preparing technology and pharmaceutical properties. The Astaxanthin Gelatin-Gum Arabic microspheres were prepared by emulsion cross-linking method using gelatin and Gum Arabic as carrier and Astaxanthin as core material. The preparation technology was optimized by orthogonal test. The absorbance of Astaxanthin was determined by UV spectrophotometer, the entrapment efficiency and drug loading capacity of the Astaxanthin microspheres were calculated, and the release value of Astaxanthin microspheres was determined. The Astaxanthin Gelatin-Gum Arabic microspheres had a good appearance, with the entrapment efficiency of 93.28%, the drug loading of 9.91%, the mean particle size of 39.75μm. The optimum processing method, with good reproducibility, of Astaxanthin Gelatin microspheres was: the ratio of oil to water of 4∶1, the concentration of gelatin of 15%, the emulsifying temperature of 60 ℃. The preparation technology of Astaxanthin Gelatin-Gum Arabic microspheres was stable and feasible, which could provide the basis for improving astaxanthin oil smell and preparing solid functional food of Astaxanthin by pharmaceutical technology.