Grain waste and economic losses caused by mycotoxin happened every year in the world. Nonetheless, prevention and control of these toxic secondary metabolites remain difficult. MyToolBox, a four-year project which has received funding from EU’s Horizon 2020, proposes an integrated, affordable and practical mycotoxin management system covering the whole chain, from field, harvest, drying, storage, food processing, to waste management alternative energy, to ensure food and feed security and safety. This paper presents an overview of MyToolBox mycotoxin integrated management system and puts forward suggestions for its application in China.