Wheat bran is the main by-product during the milling process of wheat flour, which is rich in bioactive substances. It could be used as the substrate for microbial growth in the process of solid-state fermentation and in various industrial production fields. The current research and application of solid- state fermented wheat bran in metabolites production, microbial inoculums preparation, whole-grain food processing, and feed substitution were reviewed in this study, and their prospects were also put forward, in order to provide a theoretical reference for the further and systematic research of wheat bran solid-state fermentation.