Feed antibiotics have played a great role in disease prevention and growth promotion, but in the past years, the negative problems caused by antibiotics, such as drug residues and bacterial resistance, have caused serious harm to human production and life. In recent years, some feed additives have been used in livestock and poultry breeding industry to resist disease, promote growth and play a role in replacing antibiotics. To provide support for the research and development of reducing or replacing antibiotic technology in livestock and poultry industry, the application effects of probiotics, acidification agent, plant extracts, enzyme preparation, antibacterial peptides, etc. in improving animal immunity, promoting intestinal development, ameliorating intestinal microecological environment, and enhancing feed digestibility were reviewed in this paper.