A new application of baking soda was developed, the synthetic colorant in cereal was extracted by adding with methanol solution in this paper. To develop new uses of edible bicarbonate, synthetic colorants were extracted from cereals by adding methanol water solution of edible bicarbonate in this paper, Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to test standard recovery. The extraction effect of edible bicarbonate of soda on five synthetic colorants of sunset yellow, amaranth red, carmine red, alluvium red and bright blue in cereals was investigated. The sample was extracted with 70 mL 40% methanol water vortexed with 1g edible baking soda, purified with Strata X-AW SPE column and determined. The results showed that, a good linearity was observed between 0.1 and 1.4μg/mL, and for the 5 synthetic colorants, the limit of detection was between 0.07 and 0.50 μg/g. The recoveries of the 5 synthetic colorants of different food substrates at different spiked levels (1, 2 and 10 μg/g) were all found to be in the recovery range specified in GB/T27404. The recoveries for the 5 synthetic colorants were found between 80.0% and 110% with RSD from 0.7% to 5.1% (n=6). Hence, baking soda added to 40% methanol water solution can be used to extract synthetic colorants from grain products with simple operation, accurate results, high efficiency and environmental protection.