To analyze the application of dietary intervention combined exercise in health management of overweight and obese college students. 107 overweight and obese college students who received intervention were selected as the research object and divided into control and combined group which were implemented conventional intervention and diet combined exercise intervention respectively. After intervention, the obesity-related indexes, physical function and quality indexes, lipid metabolism indexes and compliance of the combined group were better than those of the control group (P<0.05). Conclusion: the application of dietary intervention combined exercise method can effectively improve the physical function of overweight and obese college students, improve their physical quality and provide good support for their health management.