A method for simultaneous determination of 9 kinds of plasticizers and 5 kinds of antioxidants in edible vegetable oil by solid phase extraction (SPE) -gas chromatography (GC) was established and evaluated. The results showed that the limit of detection of the method was 0.024~0.087 mg/kg, and the correlation coefficient R2 ≥ 0.999 1 in the range of 0.1~50 mg/L. The recoveries in food simulation solution and edible vegetable oil were 76.90%~123.35%, and the relative standard deviation (RSD) was 1.47%~8.85%. This method is stable and reliable, and it can be used for simultaneous analysis of multiple plasticizers and antioxidants in edible vegetable oil. Besides, some plasticizers and antioxidants residues were detected in the selected 14 kinds of samples.