Since the advent of genetically modified food, its safety has been controversial. The people attach great importance to genetically modified food, and are particularly concerned about genetically modified grain. In 2016, the total area of genetically modified crops grown in the world reached 185.1 million hectares. Soybeans and corn are the two genetically modified crops with the largest planting area. Genetically modified soybean and maize are both main genetically modified grain that China imported. The management of genetically modified organisms in the United States, Brazil and the European Union from the aspects of genetically modified crop planting, management department, regulations, and identification system, was introduced. The problems on the supervision and administration of quality and safety of genetically modified grain during purchase and storage process in China were analyzed, and the corresponding policy recommendations were provided.