The pigment extracted from chrysanthemum by hot water method was selected as the investigate object,and purified by DM-28 macroporous resin. Static-dynamic purification conditions of the water-soluble pigments of chrysanthemum were optimized. The stability of the pigment was analyzed. The results showed that the optimal static adsorption-desorption conditions were as follow: adsorption equilibrium time was 3 h, the concentration of sample was the fluid diluted 12 times from the original (namely A390=0.361), sample pH was 2.5, adsorption temperature was 30℃, with pH 3.0, 50% ethanol as eluent for desorption. The optimal dynamic adsorption conditions were: sample concentration was A390=0.361, the sample flow rate was 2.0mL/min, eluted with the flow rate of 1.0mL/min, 80% ethanol. The color value of the purified pigment was 22.5, which was 3.65 times of the former. DM-28 macroporous resin show better comprehensive adsorption property. The pigment was of relatively better stability, could be used as a kind of natural food additive in the food industry.