The liquid chromatography-time of flight mass spectrometry was used to detect the contamination level of aflatoxin (AFB1, AFB2, AFG1, AFG2), fumonisin (FB1, FB2, FB3), deoxynivalenol (DON) and zearalenone (ZEN) on the maize samples harvested during 2013~2014 in Shandong province, 520 batches. The results showed that the detection rates of AFB1, AFB2, AFG1 were 18.08%, 7.88% and 0.77%, the average contents were 7.62 µg/kg，0.60 µg/kg and 0.05µg/kg; the detection rates of FB1, FB2, FB3 were 92.50%, 88.08% and 83.85%, the average contents were 1798. 69 µg/kg, 531.83µg/kg and 197.71 µg/kg; the detection rate of DON was 26.35%, the average content was 240.44 µg/kg; the detection rate of ZEN was 14.62%, the average content was 74.90 µg/kg. While none of maize samples were contaminated by aflatoxin G2. In addition, the results indicated that FBs contamination in maize was one of the most severe problem, and the over standard rate was 33.46%, and the other severe problem was the composite contamination by multiple mycotoxins.