Phosphine resistance of main stored grain insects such as Rhizopertha dominica (Fabricius) and Sitophilus oryzae( Linné) increased and , controlling insects by only PH3 was more difficulty than ever. Low oxygen concentrations were used to control lesser grain borer and rice weevil and offspring with different resistance level to phosphine. The results showed that lesser grain borer and rice weevil adult can be all killed in 2 % oxygen concentrations within 6 days, without offspring, lesser grain borer and rice weevil adult can be killed less than 50 % in 5 % oxygen concentrations after 28 days, without offspring