Coarse cereals have been proved by numerous studies that have health benefits to people，while the mechanisms still remain unclear.Molecular Nutrition is a relatively new discipline which uses the molecular biology techniques to study the metabolic mechanism of nutrients and evaluate the nutritional requirements and value of food.In this paper，the progress and problems in the evaluation of the health functions of coarse cereal based on the molecular nutrition methods were reviewed.We hope this review would be helpful for the further understanding on the mechanisms of coarse cereal healthy effects.