The determination of aluminum in puffed food by microwave digestion-inductively coupled plasma-mass spectrometry was established. The puffed food was treated by microwave digestion, with internal standard elements to compensate matrix effect, combined with the dynamic reaction cell technology to eliminate the interference of mass spectrometry, analyzed by inductively coupled plasma mass spectrometry. Under the optimal experimental conditions, aluminum showed a good linear relationship in the concentration range of 0.1~1.0 mg/L, the linear correlation coefficient r=0.999 7, the detection limit 0.023 mg/L (n=11), the recovery of standard addition 90.8%~103.0%, relative standard deviation 0.4%~3.2%. This method is rapid, simple, accurate and high sensitivity, etc., which was suitable for the determination of puffed food.