The effects of lipin on blood lipid were compared by gavaging mice with lard, peanut oil，olive oil or the triolein with high cholesterol emulsions or high dose of one of the edible oils, respectively. Results showed that the serum total cholesterol (TC) and liver index increased significantly, and the level of total triglyceride (TG) in serum decreased, after the mice were gavaged with one of the three edible oils or the triolein with high cholesterol emulsions. After being gavaged with one of the three oils, TC of the mice was increased by each of the oils. The serum levels of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and body weight were all increased because of the three oils or triolein. Meanwhile, olive oil, lard and triolein increased the liver index. In conclusion, lard, peanut oil, or olive oil mixed with cholesterol can increase serum total cholesterol level; however, there was no evidence showing that high dose of oils caused hypertriglyceridemia; peanut oil was most not likely to cause fat accumulation in the liver; triolein has no obvious influence on increasing TC, and no significant improving effect on the rise of total cholesterol level caused by cholesterol mixed with oils.