The simulation technology has been applied in grain storage ecosystem following the development of information technology, and has been an important tool for the research on interactive influence among multi-factors. Combining with the structure and characters of grain storage ecosystem, the research progress and application status of the followed area was introduced in detail: environment and ecology subsystem, computer simulations for grain pile non-biological field under no manual intervention conditions, simulation research in mechanical ventilation of grain storage, computer simulation research for the detection and precontrol of storage pests, and simulation research for growth model and precontrol of storage microorganisms.The characteristics of individual field effect on grain storage ecosystem will be more unequivocal by using simulation technology. Multi-parameter optimized control strategy for grain storage ecosystem will be formed gradually based on the research of multi-fields coupling theory.